Influence of enzymes desaturases and elongases on lipid metabolism by type 2 diabetes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39900000" target="_blank" >RIV/00216275:25310/15:39900000 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Influence of enzymes desaturases and elongases on lipid metabolism by type 2 diabetes
Original language description
Objectives: This study evaluates the activity of D5, D6, D9 desaturases and elongases in all classes of lipids in diabetic patients and control group. We processed dependency of individual monitored enzymes on the content of glycated hemoglobin. Finally,the study includes statistical evaluation of measured values of fatty acids and available biochemical markers. Methods: Lipid extracts from deproteinated plasma samples were separated by preparative thin-layer chromatography into five fractions (phospholipids, diacylglycerols, free fatty acids, triglycerides and cholesterol esters). All fractions were isolated and after the addition of internal standard (cis-13,16,19-docosatrienoic acid, 10 ?g / ml) hydrolyzed and converted to corresponding methyl esters of fatty acids. Thus prepared samples were analyzed using a gas chromatograph. Conclusions: From the results obtained it is evident that the activity D9 desaturase is similar in diabetic and control groups. They also found a correlatio
Czech name
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Czech description
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
4th International Miniconference of PhD Students: When Biochemistry Meets Pharmacology and Toxicology
ISBN
978-80-971042-5-2
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
37-41
Publisher name
Ústav experimentálnej farmakológie a toxikológie SAV
Place of publication
Bratislava
Event location
Bratislava
Event date
Jun 24, 2015
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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