Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39900072" target="_blank" >RIV/00216275:25310/15:39900072 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/15:67647 RIV/00216208:11160/15:10312334
Result on the web
<a href="http://dx.doi.org/10.1016/j.phytol.2015.08.004" target="_blank" >http://dx.doi.org/10.1016/j.phytol.2015.08.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.phytol.2015.08.004" target="_blank" >10.1016/j.phytol.2015.08.004</a>

Result language
angličtina
Original language name
Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells
Original language description
The treatment of many diseases is highly dependent on natural products and natural products can also be used as design templates for future anticancer drugs. Thirteen Amaryllidaceae alkaloids possessing alpha-crinane, beta-crinane, galantamine, lycorine and tazettine-type skeleton have been isolated in our laboratory, and their cytotoxicity against p53-mutated gastrointestinal cancer cells were evaluated. At the same time, healthy small intestine cells were used to determine overall toxicity against noncancerous cells. In this study, we demonstrated that haemanthamine, haemanthidine and lycorine showed strong cytotoxicity against p53-mutated Caco-2 and HT-29 colorectal adenocarcinoma cells as quantified in terms of IC50 values. We for the first time observed approximately 20 times higher IC(50)values against normal intestine epithelial cells FHs-74 Int after haemanthamine and lycorine treatment when compared with Caco-2 and HT-29 cancer cells. In conclusion, our data indicate that alpha-C2 bridged haemanthamine may be perspective anticancer drug candidate for further semisynthetic modification and structure-activity relationship study.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/EE2.3.20.0235" target="_blank" >EE2.3.20.0235: Establishment of Research Team Focused on Experimental and Applied Biopharmacy</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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