ALP-functionalized Mesoporous Silica Nanoparticles for Antibody Labeling in Immunosensors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39901531" target="_blank" >RIV/00216275:25310/16:39901531 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
ALP-functionalized Mesoporous Silica Nanoparticles for Antibody Labeling in Immunosensors
Original language description
Currently, the new ways how to improve the sensitivity of commonly used ELISA methods for detection of biomarkers are being found. The possibility how to achieve lower detection limits is the use of secondary antibodies labeled with nanoparticles modified by enzymes instead of antibodies labelled only by enzymes. Here we present ALP-modified silica mesoporous nanoparticles utilized for labelling of anti-ApoE IgG antibodies for quantification of apolipoprotein E (ApoE) by sandwich-type magneto-imunosorbent enzyme assay combined with square wave voltammetry. In this arrangement we achieved linear calibration curve in the concentration range of 75 - 500 ng/ml.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CG - Electrochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-16549S" target="_blank" >GA15-16549S: Development of ultrasensitive magneto-immunoassay based on quantum dots/antibody probes for simultaneous electrochemical detection of cancer markers.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
XXXVI Moderní elektrochemické metody
ISBN
978-80-905221-4-5
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
109-112
Publisher name
BEST Servis
Place of publication
Ústí nad Labem
Event location
Jetřichovice
Event date
May 23, 2016
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000389898200025