Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39901669" target="_blank" >RIV/00216275:25310/16:39901669 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/16:70576 RIV/00216208:11150/16:10326633 RIV/00216208:11160/16:10326633

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types

Original language description

Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 +/- 0.87 and 4.57 +/- 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Natural Product Communications

ISSN

1934-578X

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

753-756

UT code for WoS article

000379631600014

EID of the result in the Scopus database

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