Determination of distribution constants of antioxidants between liposomes, alkylsulfate micelles, octanol and water using electrokinetic chromatography
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39901786" target="_blank" >RIV/00216275:25310/16:39901786 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Determination of distribution constants of antioxidants between liposomes, alkylsulfate micelles, octanol and water using electrokinetic chromatography
Original language description
The in vivo effects of the antioxidants are dependent on their lipophilicity, which govern membrane and protein interactions. Two electrokinetic systems, i.e. micellar electrokinetic chromatography (MEKC) and liposome electrokinetic chromatography (LEKC), were used for studying of the lipophilicity of antioxidants. Micelles of sodium decyl sulfate (SDeS) and sodium dodecyl sulfate (SDS) were used as the pseudostationary phase in MEKC and the liposomes were composed of mixtures of 1-palmitoyl-2-oleyl-sn-glycerophosphatidylcholine (POPC) and 1-palmitoyl-2-oleoylsn-phosphatidylserine (POPS) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidyl-DLglycerol (POPG) in LEKC. The retention factors of the studied analytes were determined at pH 7.4. The micelle and liposome/aqueous distribution constants for studied antioxidants were experimentally determined and compared with values of octanol/aqueous distribution constants.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA14-06319S" target="_blank" >GA14-06319S: Development of microfluidic interfaces for multidimensional liquid phase separation/mass spectrometry analysis of complex biological samples</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
CECE 2016 : 13th International Interdisciplinary Meeting on Bioanalysis
ISBN
978-80-904959-4-4
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
62-65
Publisher name
Ústav analytické chemie AV ČR, v. v. i.
Place of publication
Brno
Event location
Brno
Event date
Oct 17, 2016
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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