Determination of distribution constants of antioxidants by electrokinetic chromatography

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F17%3A39910645" target="_blank" >RIV/00216275:25310/17:39910645 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1080/23312009.2017.1385173" target="_blank" >http://dx.doi.org/10.1080/23312009.2017.1385173</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/23312009.2017.1385173" target="_blank" >10.1080/23312009.2017.1385173</a>

Result language

angličtina

Original language name

Determination of distribution constants of antioxidants by electrokinetic chromatography

Original language description

Liposome electrokinetic chromatography and micellar electrokinetic chromatography were used for studying the lipophilic properties of natural antioxidants, specifically phenolic acids and flavonoids. The employed negatively charged liposomes were composed of mixtures of 1-palmitoyl-2-oleyl-sn-glycerophosphati-dylcholine and 1-palmitoyl-2-oleoyl-sn-phosphatidylserine or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol. In micellar electrokinetic chromatography, sodium dodecyl sulphate micelles were used as the pseudostationary phase. The retention factors of the studied compounds were determined at pH 7.4. The corresponding distribution constants were calculated from the experimentally determined retention factors and the phase ratios of the liposome dispersions and the micellar system. The distribution constants between the aqueous phase and the liposomes or micelles were compared with octanol/water partition or distribution constants of the studied compounds, which were predicted using the ACD/Labs Percepta Platform-PhysChem Module. Our results indicate that the correlations between the distribution constants of the two tested liposome systems were much stronger than those between the liposome/micellar systems. The correlations between the n-octanol phase and the liposome phases were similar to that between n-octanol and the micellar phase. Our data shows that electrokinetic chromatography is an efficient method for determining partition coefficients of compounds, but the type of pseudostationary phase has a clear impact on the values.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

COGENT CHEMISTRY

ISSN

2331-2009

e-ISSN

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Volume of the periodical

3

Issue of the periodical within the volume

1

Country of publishing house

NO - NORWAY

Number of pages

11

Pages from-to

"1385173-1"-"1385173-11"

UT code for WoS article

000412345300001

EID of the result in the Scopus database

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