Recent advances in stationary phases and understanding of retention in hydrophilic interaction chromatography. A review

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F17%3A39911193" target="_blank" >RIV/00216275:25310/17:39911193 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.aca.2017.01.060" target="_blank" >http://dx.doi.org/10.1016/j.aca.2017.01.060</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aca.2017.01.060" target="_blank" >10.1016/j.aca.2017.01.060</a>

Result language
angličtina
Original language name
Recent advances in stationary phases and understanding of retention in hydrophilic interaction chromatography. A review
Original language description
Hydrophilic interaction chromatography (HILIC) is a rapidly developing liquid chromatography mode suitable for separation of strongly or moderately polar samples on polar columns in highly organic mixed mobile phases. In the past five years many new types of columns appeared based on silica gel, organic polymers and other types of supports. The present work reviews the new additions to their family. Further, the progress in the understanding of theoretical principles of the HILIC mode, especially of the role of the mobile phase, and of the adsorbed water are addressed. The amount of adsorbed water strongly depends on the type of the polar column and may be used to distinguish between "conventional HILIC" and " aqueous normal phase chromatography (ANP)". Further, sample structural effects on the retention are treated in terms of the Linear Solvation Energy Relationship model adopted for partially ionized polar compounds. The impact of dual HILIC-reversed phase (RP) mechanism on a possible increase of the applications of some polar columns is discussed. Attention is paid also to the increasing role of the HILIC mode in various two-dimensional LC techniques and the related mobile phase compatibility problems.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
<a href="/en/project/GAP206%2F12%2F0398" target="_blank" >GAP206/12/0398: Two-dimensional separations in liquid media</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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