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Monolithic Capillary Column with an Integrated Electrochemical Detector

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F17%3A39911330" target="_blank" >RIV/00216275:25310/17:39911330 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/17:00113892

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0021967317309251" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0021967317309251</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.chroma.2017.06.057" target="_blank" >10.1016/j.chroma.2017.06.057</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Monolithic Capillary Column with an Integrated Electrochemical Detector

  • Original language description

    The carbon fiber and silver microwire were used as working and pseudoreference electrode, respectively, and inserted into the ending of capillary to prepare monolithic capillary column with an integrated electrochemical detector. Prepared capillary devices offered stable and robust results with relative standard deviations of retention, resolution, and detection signal lower than 1.5, 5.5, and 5.0%, respectively. To further increase sensitivity of developed electrochemical microdetector, multiple pulse amperometry detection mode has been used. Optimized integrated device provided reliable chromatographic separation of mixture of neurotransmitters with calibration curve for dopamine linear from 0.5 to 20.0 mg L-1 and an instrumental limit of detection as low as 24 pg of injected dopamine. Finally, developed capillary column was applied to successful determination of dopamine in a human urine. By using both calibration curve and standard addition method, the dopamine level was determined to be 0.74 +/- 0.03 mgL(-1) and 0.71 +/- 0.02 mgL(-1), respectively. Triplicates of dopamine analysis provided relative standard deviations lower than 2.7% for intraday analyses, while interday relative standard deviations were lower than 3.6% for five consecutive days.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

    <a href="/en/project/GA14-22426S" target="_blank" >GA14-22426S: Development of an multifunctional monolithic capillary column with integrated sample focusing, separation, and on-column electrochemical detection</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Chromatography A

  • ISSN

    0021-9673

  • e-ISSN

  • Volume of the periodical

    1509

  • Issue of the periodical within the volume

    August

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    5

  • Pages from-to

    171-175

  • UT code for WoS article

    000407868800020

  • EID of the result in the Scopus database