Antimicrobial effect of OKCEL® H-D prepared from oxidized cellulose

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F18%3A39911306" target="_blank" >RIV/00216275:25310/18:39911306 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s12223-017-0534-7" target="_blank" >https://link.springer.com/article/10.1007/s12223-017-0534-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12223-017-0534-7" target="_blank" >10.1007/s12223-017-0534-7</a>

Result language
angličtina
Original language name
Antimicrobial effect of OKCEL® H-D prepared from oxidized cellulose
Original language description
The antimicrobial effect of OKCEL® H-D, a topical, absorbable hemostatic textile prepared from oxidized cellulose, was tested. Testing by dilution and diffusion methods was conducted on a spectrum of 27 select microorganisms, including also antibiotic-resistant strains. OKCEL® H-D showed inhibitory effects on nearly all tested bacteria. In testing using the dilution suspension method, the majority of bacteria showed decrease in cell density by 7–8 orders of magnitude after just 6 h of exposure. For clinical isolates of antibiotic-resistant strains, a reduction occurred after 24 h of exposure. In testing the antimicrobial effects of OKCEL® H-D by the dilution method was least effective on spore-forming Bacillus subtilis, for which no antimicrobial effect was detected after 48 h, and on Mycobacterium smegmatis, for which the number of cells decreased by 4 orders of magnitude only after 24 h. By the diffusion method, inhibition zones were recorded for nearly all test microorganisms except for Staphylococcus aureus, M. smegmatis, and Listeria monocytogenes. No growth beneath the tested OKCEL® H-D material was recorded, however, even for the latter-named bacteria strains, which attests to its good inhibitory effect.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology

Project
<a href="/en/project/2A-1TP1%2F073" target="_blank" >2A-1TP1/073: *New pharmaceutical products based on polysaccharides</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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