Antimicrobial Activity of Polyhexamethylene Guanidine Derivatives Introduced into Polycaprolactone
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F18%3A39912721" target="_blank" >RIV/00216275:25310/18:39912721 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10924-017-0974-9" target="_blank" >http://dx.doi.org/10.1007/s10924-017-0974-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10924-017-0974-9" target="_blank" >10.1007/s10924-017-0974-9</a>
Alternative languages
Result language
angličtina
Original language name
Antimicrobial Activity of Polyhexamethylene Guanidine Derivatives Introduced into Polycaprolactone
Original language description
The research was aimed at determining the abundance of biofilm formation by Escherichia coli and Staphylococcus aureus on the surface of polycaprolactone (PCL) with polyhexamethylene guanidine (PHMG) derivatives and effect of the derivatives on extracellular hydrolytic enzymes and intracellular dehydrogenases. Biofilm abundance was determined by spectrophotometry, using crystal violet staining. Hydrolytic enzymes after contact with the film were determined with the use of non-specific substrate-fluorscein diacetate. The effect of PHMG derivatives on dehydrogenases activity was assessed using the test, where triphenyltetrazolium chloride (TTC) is reduced to triphenylformazan (TF). The PCL containing PHMG granular polyethylene wax and salt of sulfanilic acid (0.6-1% wt.) strongest inhibited biofilm formation. PHMG derivatives introduced into PCL were found to slightly affect hydrolases activity in both E. coli and S. aureus at a concentration of 0.2 and 0.6%. It was also found that dehydrogenases activity was inhibited by PCL films containing PHMG derivatives. PCL containing 1% of PHMG sulfanilate strongest inhibited hydrolases activity, whereas PCL modified with 1% of PHMG granular polyethylene wax showed the highest inhibitory effect on the activity of both enzymes. W-PCL and A-PCL composites (at concentration of 0.6%) have optimal combination of antibiofilm activity and biodegradability.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Polymers and the Environment
ISSN
1566-2543
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
589-595
UT code for WoS article
000425964600016
EID of the result in the Scopus database
2-s2.0-85014056015