A porcine model of skin wound infected with a polybacterial biofilm

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F18%3A39914242" target="_blank" >RIV/00216275:25310/18:39914242 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/18:00495966 RIV/00216208:11120/18:43916259 RIV/00216208:11140/18:10369468 RIV/00216208:11150/18:10369468 and 2 more
Result on the web
<a href="https://www.tandfonline.com/doi/abs/10.1080/08927014.2018.1425684" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/08927014.2018.1425684</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/08927014.2018.1425684" target="_blank" >10.1080/08927014.2018.1425684</a>

Result language
angličtina
Original language name
A porcine model of skin wound infected with a polybacterial biofilm
Original language description
A clinically relevant porcine model of a biofilm-infected wound was established in 10 minipigs. The wounds of six experimental animals were infected with a modified polymicrobial Lubbock chronic wound biofilm consisting of Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Bacillus subtilis. Four animals served as uninfected controls. The wounds were monitored until they had healed for 24 days. The biofilm persisted in the wounds up to day 14 and significantly affected healing. The control to infected healed wound area ratios were: 45%/21%, 66%/37%, and 90%/57% on days 7, 10 and 14, respectively. The implanted biofilm prolonged inflammation, increased necrosis, delayed granulation and impaired development of the extracellular matrix as seen in histological and gene expression analyses. This model provides a therapeutic one-week window for testing of anti-biofilm treatments and for research on the pathogenesis of wound infections in pig that is clinically the most relevant animal wound healing model.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20801 - Environmental biotechnology

Project
<a href="/en/project/TA03011029" target="_blank" >TA03011029: New wound dressings with programmed release of active substances for biofilm inhibition.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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