Synthesis of 13,14-Dehydro-prostaglandins Synthetic Analogues: A Review

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39914612" target="_blank" >RIV/00216275:25310/19:39914612 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/19:10399697
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201902679" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201902679</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/slct.201902679" target="_blank" >10.1002/slct.201902679</a>

Result language
angličtina
Original language name
Synthesis of 13,14-Dehydro-prostaglandins Synthetic Analogues: A Review
Original language description
Prostaglandins (PG) are a group of lipid mediators with several biological activities. Their structure includes a five-membered ring and two lateral chains (alpha and omega- chains). Due to their pharmaceutical and veterinary applications numerous synthetic analogues have been prepared and are described in literature. 13,14-dehydroPG are synthetic analogues including a triple bond in their skeleton which provide them a more preferable biological behaviour. However, these compounds require special approaches for their synthesis and attachment of its omega-chain when compared with allylic PG (double bond at position 13-14 of PG numbering). This review intends to summarize available strategies for the introduction of the omega-chains when a triple bond moiety (at position C13-14) is present.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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