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Colloidally stable polypeptide-based nanogel: Study of enzyme-mediated nanogelation in inverse miniemulsion

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39914952" target="_blank" >RIV/00216275:25310/19:39914952 - isvavai.cz</a>

  • Alternative codes found

    RIV/61389013:_____/20:00522680

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/app.48725" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/app.48725</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/app.48725" target="_blank" >10.1002/app.48725</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Colloidally stable polypeptide-based nanogel: Study of enzyme-mediated nanogelation in inverse miniemulsion

  • Original language description

    The current work presents a pivotal study of the nanogelation of the linear poly(N-5-2-hydroxypropyl-L-glutamine) polymer precursor containing tyramine (TYR) units in an inverse miniemulsion by horseradish peroxidase/H2O2-mediated crosslinking. The effects of various n(H2O2)/n(TYR) ratios on the kinetics of nanogelation in the inverse miniemulsion and on the reaction time are investigated by linear sweep voltammetry, while the formation of dityramine crosslinking is explored by fluorescence spectroscopy. The study is completed using dynamic light scattering measurements, nanoparticle tracking analysis, and cryogenic transmission electron microscopy to acquire comprehensive information about the formed nanoparticulate systems. With the optimal ratio n(H2O2)/n(TYR) = 2, the strategy yields in the high-quality 130 nm poly(amino acid)-based nanogel, which is prepared in 2 h. The nanogel is colloidally stable under different temperature and pH conditions for over 168 h. Moreover, the demonstrated nanogel is noncytotoxic for HeLa cells and human primary fibroblasts and is quickly enzymatically hydrolyzed into small fragments during a biodegradation study in human blood plasma. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48725.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    21001 - Nano-materials (production and properties)

Result continuities

  • Project

    <a href="/en/project/GA18-03224S" target="_blank" >GA18-03224S: INJECTABLE POLYPEPTIDE BASED HYDROGELS MIMICKING THE DYNAMIC PROCESSES IN EXTRACELLULAR MATRIX</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Applied Polymer Science

  • ISSN

    0021-8995

  • e-ISSN

  • Volume of the periodical

    137

  • Issue of the periodical within the volume

    21

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    "48725-1"-"48725-10"

  • UT code for WoS article

    000496555800001

  • EID of the result in the Scopus database