Comprehensive proteomic investigation of infectious and infammatory changes in late preterm prelabour rupture of membranes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F20%3A39916289" target="_blank" >RIV/00216275:25310/20:39916289 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41598-020-74756-9" target="_blank" >https://doi.org/10.1038/s41598-020-74756-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-020-74756-9" target="_blank" >10.1038/s41598-020-74756-9</a>
Alternative languages
Result language
angličtina
Original language name
Comprehensive proteomic investigation of infectious and infammatory changes in late preterm prelabour rupture of membranes
Original language description
Preterm prelabour rupture of membranes beyond the 34th week of gestation (late PPROM) is frequently associated with the risk of the microbial invasion of the amniotic fluid (MIAC) and histological chorioamnionitis (HCA). Hence, we employed a Tandem Mass Tag-based approach to uncover amniotic fluid proteome response to the presence of MIAC and HCA in late PPROM. Protein dysregulation was associated with only five cases in the group of 15 women with confirmed MIAC and HCA. Altogether, 138 amniotic fluid proteins were changed in these five cases exclusively. These proteins were particularly associated with excessive neutrophil responses to infection, such as neutrophil degranulation and extracellular trap formation. We believe that the quantification of these proteins in amniotic fluid may assist in revealing women with the highest risk of excessive inflammatory response in late PPROM.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
17696
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
"17696 -1"-"17696 -14"
UT code for WoS article
000585197800026
EID of the result in the Scopus database
2-s2.0-85092778246