Comprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00538100" target="_blank" >RIV/67985823:_____/20:00538100 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/20:10418121 RIV/00216208:11150/20:10418121 RIV/00216208:11160/20:10418121 RIV/00179906:_____/20:10418121
Result on the web
<a href="https://www.nature.com/articles/s41598-020-74756-9" target="_blank" >https://www.nature.com/articles/s41598-020-74756-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-020-74756-9" target="_blank" >10.1038/s41598-020-74756-9</a>

Result language
angličtina
Original language name
Comprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes
Original language description
Preterm prelabour rupture of membranes beyond the 34th week of gestation (late PPROM) is frequently associated with the risk of the microbial invasion of the amniotic fluid (MIAC) and histological chorioamnionitis (HCA). Hence, we employed a Tandem Mass Tag-based approach to uncover amniotic fluid proteome response to the presence of MIAC and HCA in late PPROM. Protein dysregulation was associated with only five cases in the group of 15 women with confirmed MIAC and HCA. Altogether, 138 amniotic fluid proteins were changed in these five cases exclusively. These proteins were particularly associated with excessive neutrophil responses to infection, such as neutrophil degranulation and extracellular trap formation. We believe that the quantification of these proteins in amniotic fluid may assist in revealing women with the highest risk of excessive inflammatory response in late PPROM.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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