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Comprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00538100" target="_blank" >RIV/67985823:_____/20:00538100 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/20:10418121 RIV/00216208:11150/20:10418121 RIV/00216208:11160/20:10418121 RIV/00179906:_____/20:10418121

  • Result on the web

    <a href="https://www.nature.com/articles/s41598-020-74756-9" target="_blank" >https://www.nature.com/articles/s41598-020-74756-9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/s41598-020-74756-9" target="_blank" >10.1038/s41598-020-74756-9</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Comprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes

  • Original language description

    Preterm prelabour rupture of membranes beyond the 34th week of gestation (late PPROM) is frequently associated with the risk of the microbial invasion of the amniotic fluid (MIAC) and histological chorioamnionitis (HCA). Hence, we employed a Tandem Mass Tag-based approach to uncover amniotic fluid proteome response to the presence of MIAC and HCA in late PPROM. Protein dysregulation was associated with only five cases in the group of 15 women with confirmed MIAC and HCA. Altogether, 138 amniotic fluid proteins were changed in these five cases exclusively. These proteins were particularly associated with excessive neutrophil responses to infection, such as neutrophil degranulation and extracellular trap formation. We believe that the quantification of these proteins in amniotic fluid may assist in revealing women with the highest risk of excessive inflammatory response in late PPROM.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Scientific Reports

  • ISSN

    2045-2322

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    14

  • Pages from-to

    17696

  • UT code for WoS article

    000585197800026

  • EID of the result in the Scopus database

    2-s2.0-85092778246