Lipidomic profiling of human serum enables detection of pancreatic cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F22%3A39918847" target="_blank" >RIV/00216275:25310/22:39918847 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/22:10437035 RIV/00098892:_____/22:10157344 RIV/61989592:15110/22:73610018 RIV/00064165:_____/22:10437035 and 4 more
Result on the web
<a href="https://www.nature.com/articles/s41467-021-27765-9" target="_blank" >https://www.nature.com/articles/s41467-021-27765-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-021-27765-9" target="_blank" >10.1038/s41467-021-27765-9</a>

Result language
angličtina
Original language name
Lipidomic profiling of human serum enables detection of pancreatic cancer
Original language description
Pancreatic cancer has the worst prognosis among all cancers. Cancer screening of body fluids may improve the survival time prognosis of patients, who are often diagnosed too late at an incurable stage. Several studies report the dysregulation of lipid metabolism in tumor cells, suggesting that changes in the blood lipidome may accompany tumor growth. Here we show that the comprehensive mass spectrometric determination of a wide range of serum lipids reveals statistically significant differences between pancreatic cancer patients and healthy controls, as visualized by multivariate data analysis. Three phases of biomarker discovery research (discovery, qualification, and verification) are applied for 830 samples in total, which shows the dysregulation of some very long chain sphingomyelins, ceramides, and (lyso) phosphatidylcholines. The sensitivity and specificity to diagnose pancreatic cancer are over 90%, which outperforms CA 19-9, especially at an early stage, and is comparable to established diagnostic imaging methods. Furthermore, selected lipid species indicate a potential as prognostic biomarkers.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10406 - Analytical chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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