Addressing polar solvent challenges in the heterogenization of palladium catalysed Hayashi-Miyaura reaction on polymer support

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F23%3A39920802" target="_blank" >RIV/00216275:25310/23:39920802 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S138151482300250X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S138151482300250X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.reactfunctpolym.2023.105747" target="_blank" >10.1016/j.reactfunctpolym.2023.105747</a>

Result language
angličtina
Original language name
Addressing polar solvent challenges in the heterogenization of palladium catalysed Hayashi-Miyaura reaction on polymer support
Original language description
The development of recyclable heterogeneous catalysts for the palladium-catalysed additions of arylboronic acids to nitrostyrenes is investigated in this study. Two strategies, direct copolymerization and post-modification, are explored for immobilizing chiral isoquinoline-oxazoline ligands onto polymer matrices. Various copolymer formulations are prepared, and their catalytic activity, recyclability, and reaction kinetics are evaluated. The incorporation of polar functional groups into the polymer matrix enhances catalytic properties, albeit with a decrease in reaction rate compared to the homogeneous system. Post-modification using a polystyrenepolyethylene glycol (PS-PEG) support shows promise, resulting in a moderate decrease in reaction rate and satisfactory performance over multiple reaction cycles. The findings provide valuable insights into the immobilization of chiral ligands and highlight the advantages and limitations of different polymer compositions. These results contribute to the development of advanced catalytic systems for the synthesis of biologically relevant compounds.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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