Recent advances in separation methods for characterization of glutathione metabolism and dietary supplementation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F24%3A39921478" target="_blank" >RIV/00216275:25310/24:39921478 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0165993624002346" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0165993624002346</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trac.2024.117751" target="_blank" >10.1016/j.trac.2024.117751</a>
Alternative languages
Result language
angličtina
Original language name
Recent advances in separation methods for characterization of glutathione metabolism and dietary supplementation
Original language description
Glutathione (GSH) is the most important low-molecular intracellular antioxidant. In addition to its antioxidant properties, it ensures many other biological functions, including the elimination of xenobiotics. Glutathione and glutathione disulfide (GSSG) levels can be used as biomarkers of oxidative stress associated with many physiological and pathological conditions at which intracellular GSH levels decrease. Thus enhancing intracellular GSH levels has a wide therapeutic potential. A promising candidate for effective elevation of intracellular GSH levels by simple supplementation is γ-glutamylcysteine. The present review is focused on the description of available methods for characterization of GSH metabolism. Especially, methods utilizing liquid chromatography and liquid chromatography coupled with mass spectrometry for the determination of GSH, GSSG, and otherthiols and related compounds are reviewed and critically discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/GA22-09556S" target="_blank" >GA22-09556S: Self-adaptive multidimensional liquid phase separations</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
TrAC - Trends in Analytical Chemistry
ISSN
0165-9936
e-ISSN
1879-3142
Volume of the periodical
176
Issue of the periodical within the volume
July 2024
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
14
Pages from-to
117751
UT code for WoS article
001294703200001
EID of the result in the Scopus database
2-s2.0-85192951171