Recent advances, challenges, and future directions in the mass spectrometry analysis of glycosphingolipids in biological samples

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F24%3A39921963" target="_blank" >RIV/00216275:25310/24:39921963 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/24:43908817
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0165993624003108?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0165993624003108?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trac.2024.117827" target="_blank" >10.1016/j.trac.2024.117827</a>

Result language
angličtina
Original language name
Recent advances, challenges, and future directions in the mass spectrometry analysis of glycosphingolipids in biological samples
Original language description
Mass spectrometry combined with (ultra)high-performance liquid chromatography has proved to be the most suitable method for the analysis of glycosphingolipids (GSLs). An increasing number of studies have focused on the analysis of not only simple but also complex GSLs with the aim of clarifying their biochemical functions in animals and humans. Despite the tremendous improvements in sample preparation and analytical methods in glycosphingolipidomics, there are still several major issues that complicate the comprehensive analysis of GSLs. This review aims to provide the latest advances, developments, and instrumental innovations in the analysis of GSLs in biological samples. The current barriers and challenges facing the qualitative and quantitative analysis of GSLs are highlighted and critically assessed. Overcoming these bottlenecks is crucial for high-throughput GSLs profiling, which is essential to reveal their clinical potential and to understand their role in the pathophysiology of serious diseases, such as cancer.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10400 - Chemical sciences

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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