Structure-based constitutive model can accurately predicts planar biaxial properties of arotic wall tissue

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F15%3APU113149" target="_blank" >RIV/00216305:26210/15:PU113149 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.actbio.2014.11.043" target="_blank" >http://dx.doi.org/10.1016/j.actbio.2014.11.043</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.actbio.2014.11.043" target="_blank" >10.1016/j.actbio.2014.11.043</a>

Result language

angličtina

Original language name

Structure-based constitutive model can accurately predicts planar biaxial properties of arotic wall tissue

Original language description

Introduction. Structure-based constitutive models might help exploring mechanisms by which arterial wall histology is linked to wall mechanics. This study aims at validating a recently proposed structure-based constitutive model. Specifically, the models ability to predict mechanical biaxial response of porcine aortic tissue with predefined collagen structure was tested. Materials and Methods. Histological slices from porcine thoracic aorta wall (n=9) were automatically processed to quantify the collagen fiber organization, and mechanical testing identified non-linear properties of the wall samples (n=18) over a wide range of biaxial stretches. Histological and mechanical experimental data was used to identify model parameters of a multi-scale constitutive description for arterial layers proposed recently. The model predictive capability was tested with respect to interpolation and extrapolation. Results. Collagen in the media was predominantly aligned in circumferential direction (planar von Mises distribution with concentration parameter b_M=1.03±0.23), and its coherence decreased gradually from the luminal to the abluminal tissue layers (inner media: b=1.54±0.40; outer media: b=0.72±0.20). In contrast, the collagen in the adventitia was aligned almost isotropically (b_A=0.27±0.11), and no features like families of coherent fibers were identified. The applied constitutive model captured the aorta biaxial properties accurately (coefficient of determination R^2=0.95±0.03) over the entire range of biaxial deformations and with physically meaningful model parameters. Good predictive properties, well outside the parameter identification space, were observed (R^2=0.92±0.04). Conclusions. Multi-scale constitutive models equipped with realistic micro-histological data can predict macroscopic non-linear aorta wall properties. Collagen largely defines already low strain properties of media, which explains the origin of wall anisotropy seen at this strain level. Structure

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10610 - Biophysics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Biomaterialia

ISSN

1742-7061

e-ISSN

1878-7568

Volume of the periodical

14

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

133-145

UT code for WoS article

000349733800014

EID of the result in the Scopus database

2-s2.0-84921839868