The composition and biomechanical properties of human cryopreserved aortas, pulmonary trunks, and aortic and pulmonary cusps
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F17%3A43931702" target="_blank" >RIV/49777513:23520/17:43931702 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/17:10358993 RIV/00216208:11140/17:10358993 RIV/00064203:_____/17:10358993
Result on the web
<a href="http://dx.doi.org/10.1016/j.aanat.2017.03.004" target="_blank" >http://dx.doi.org/10.1016/j.aanat.2017.03.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aanat.2017.03.004" target="_blank" >10.1016/j.aanat.2017.03.004</a>
Alternative languages
Result language
angličtina
Original language name
The composition and biomechanical properties of human cryopreserved aortas, pulmonary trunks, and aortic and pulmonary cusps
Original language description
Human cryopreserved allografts of pulmonary and aortic heart valves, aortas and pulmonary trunks are used for valve replacement. However, it is unknown how the composition of these allografts relate to their mechanical properties. Our aims were to correlate the histological compositions and passive mechanical properties of aortic and pulmonary valves and to observe the microcracks of aortas and pulmonary trunks. The following parameters were quantified: ultimate stress; ultimate strain; Young’s modulus of elasticity; valve cusp wall thickness; pulmonary and aortic intima-media thickness; area fraction of elastin, collagen and calcification; and length density of elastic fibres. The propagation of experimentally induced microcracks avoided elastic fibres. Ultimate strain was negatively correlated with the area fraction of calcification (r =−0.4) in aortas. Ultimate stress (r = 0.27) and Young’s modulus in small deformation (r = 0.29) and in large deformation (r = 0.32) correlated with wall thickness in valve cusps. Young’s modulus (r = 0.34) and ultimate strain (r = 0.31) correlated with intima-media thickness. Ultimate strain correlated with the area fraction of elastin (r = −0.40) and collagen in the arteries (r = 0.31). As conventional histology does not fully explain the mechanical properties of cryopreserved grafts, both morphological and biomechanical tests should be used complementarily when characterizing the ageing of the grafts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20503 - Textiles; including synthetic dyes, colours, fibres (nanoscale materials to be 2.10; biomaterials to be 2.9)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
ISSN
0940-9602
e-ISSN
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Volume of the periodical
2017
Issue of the periodical within the volume
212
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
17-26
UT code for WoS article
000405057500004
EID of the result in the Scopus database
2-s2.0-85018286720