Histological Composition and Mechanical Properties of Cryopreserved Samples of Aortic and Pulmonary Valves

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F17%3A43930045" target="_blank" >RIV/49777513:23520/17:43930045 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/17:10328504 RIV/00216208:11140/17:10328504 RIV/00064203:_____/17:10328504

Result on the web

<a href="http://dx.doi.org/10.4028/www.scientific.net/SSP.258.341" target="_blank" >http://dx.doi.org/10.4028/www.scientific.net/SSP.258.341</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4028/www.scientific.net/SSP.258.341" target="_blank" >10.4028/www.scientific.net/SSP.258.341</a>

Result language

angličtina

Original language name

Histological Composition and Mechanical Properties of Cryopreserved Samples of Aortic and Pulmonary Valves

Original language description

Human cryopreserved allografts of pulmonary and aortic valves are routinely used as total valve replacement. For successful surgery it is needed to sufficiently preserve biomechanical properties and histological structures of allografts. However, it is not known how the mechanical properties of these allografts relate to their histological composition. The aim of our study was to compare the histological composition and mechanical properties of the valves. From allografts we prepared 2 valve cusps and samples of aorta or pulmonary trunk. In a previous study we had measured following parameters: ultimate stress, ultimate strain, Young’s moduli of elasticity, intima-media thickness, wall thickness, area fraction of elastin and area fraction of collagen in the whole wall. We found weak positive correlation between ultimate stress and Young’s modulus in small and large deformation with wall thickness in the valve cusps. In the arteries we found positive correlation between Young’s modulus in large deformation with intima-media thickness and ultimate strain with intima-media thickness and area fraction of collagen, and negative correlation between ultimate strain with area fraction of elastin. In our study we quantified also the other components of wall with mechanical significance, such as the fraction of smooth muscle cells and chondroitin sulfate, which belong to glycosaminoglycans. We did not find correlation between these components and mechanical properties of these valves. Therefore, it is recommended to perform both mechanical and histological analysis to further characterize cryopreserved allografts.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

20501 - Materials engineering

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Solid State Phenomena

ISBN

978-3-03835-626-4

ISSN

1662-9779

e-ISSN

neuvedeno

Number of pages

4

Pages from-to

341-344

Publisher name

Trans Tech Publications

Place of publication

Switzerland

Event location

Brno, Czech Republic

Event date

Jun 27, 2016

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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