The histological microstructure and in vitro mechanical properties of the human female postmenopausal perineal body
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F19%3A43952172" target="_blank" >RIV/49777513:23520/19:43952172 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/19:10394119
Result on the web
<a href="https://journals.lww.com/menopausejournal/Citation/2019/01000/The_histological_microstructure_and_in_vitro.10.aspx" target="_blank" >https://journals.lww.com/menopausejournal/Citation/2019/01000/The_histological_microstructure_and_in_vitro.10.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/GME.0000000000001166" target="_blank" >10.1097/GME.0000000000001166</a>
Alternative languages
Result language
angličtina
Original language name
The histological microstructure and in vitro mechanical properties of the human female postmenopausal perineal body
Original language description
Objective: The perineal body connects muscles from the pelvic floor and is critical for support of the lower part of vagina and proper function of the anal canal. We determined mechanical parameters and volume fractions of main components of human female postmenopausal perineal body. Methods: The specimens were taken from 15 fresh female cadavers (age 74 +- 10, mean +- standard deviation). Seventy-five specimens from five regions of the perineal body were processed histologically to assess volume fractions of tissue components using stereological point testing grid. Fifteen specimens taken from the midline region were loaded uniaxially with 6 mm/min velocity until tissue rupture to determine Young’s modulus of elasticity, ultimate stresses, and strains. Results: The perineal body was composed of collagen (29%), adipose cells (27%), elastin (7%), smooth muscle (11%), and skeletal muscle (3%). The residual tissue (19%) constituted mostly peripheral nerves, lumina of blood vessels, fibroblasts, and fibrocytes. Young’s modulus of elasticity at midline region was 18 kPa (median) at small and 232 kPa at large deformations, respectively. The ultimate stress was 172 kPa and the ultimate strain was 1.4. Conclusions: We determined the structural and mechanical parameters of the perineal body. The resultant data could be used as input for models simulating pelvic floor prolapse or dysfunction.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20302 - Applied mechanics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
ISSN
1072-3714
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
66-77
UT code for WoS article
000467339900010
EID of the result in the Scopus database
2-s2.0-85059159584