The histological microstructure and in vitro mechanical properties of pregnant and postmenopausal ewe perineal body
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F19%3AN0000019" target="_blank" >RIV/00023698:_____/19:N0000019 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/19:43918740 RIV/00216208:11140/19:10402400 RIV/49777513:23520/19:43957151 RIV/00669806:_____/19:10402400
Result on the web
<a href="https://doi.org/10.1097/GME.0000000000001395" target="_blank" >https://doi.org/10.1097/GME.0000000000001395</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/GME.0000000000001395" target="_blank" >10.1097/GME.0000000000001395</a>
Alternative languages
Result language
angličtina
Original language name
The histological microstructure and in vitro mechanical properties of pregnant and postmenopausal ewe perineal body
Original language description
The mechanical properties and microstructure of the perineal body are important for the improvement of numerical models of pelvic organs. We determined the mechanical parameters and volume fractions of the ewe perineal body as an animal model. METHODS: The 39 specimens of 13 pregnant swifter ewes delivering by cesarean section (aged 2 years, weight 61.2 +- 6.2 kg (mean +- standard deviation) and 24 specimens of 8 postmenopausal swifter ewes 150 days after surgical ovariectomy (aged 7 years, 58.6 +- 4.6 kg)) were loaded uniaxially to determine Young's moduli of elasticity in the small (E0) and large (E1) deformation regions, and ultimate stresses and strains. The 63 adjacent tissue samples were processed histologically to assess volume fractions of smooth and skeletal muscle, adipose cells, elastin, and type I collagen using a stereological point testing grid. We compared the structural and mechanical differences along the ewe perineal body, and between pregnant and postmenopausal groups. RESULTS: The pregnant/postmenopausal perineal body was composed of smooth muscle (12/14%; median), skeletal muscle (12/16%), collagen (10/23%), elastin (8/7%), and adipose cells (6/6%). The E0 was 37/11 kPa (median), E1 was 0.97/1.04 MPa, ultimate stress was 0.55/0.59 MPa, and ultimate strain was 0.90/0.87 for pregnant/postmenopausal perineal body. The perineal body showed a structural and mechanical stability across the sites. The pregnant ewes had a higher amount of skeletal muscle, higher E0, and a less amount of collagen when compared with postmenopausal ewes. CONCLUSIONS: The data can be used as input for models simulating vaginal delivery, pelvic floor prolapsed, or dysfunction.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Menopause
ISSN
1072-3714
e-ISSN
1530-0374
Volume of the periodical
26
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1289-1301
UT code for WoS article
000509483500011
EID of the result in the Scopus database
2-s2.0-85072100817