Computational model of vascular smooth muscle cell.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F15%3APU115243" target="_blank" >RIV/00216305:26210/15:PU115243 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Computational model of vascular smooth muscle cell.
Original language description
The cytoskeleton plays a vital role in defining the mechanical behavior of cell subjected to external mechanical stimuli. The cellular tensegrity model views the cytoskeleton as a reticulated mechanical structure, where the tensile prestress generated byactomyosin filaments is balanced internally via compression-supporting stuctures such as microtubules and externally via extracellular matrix. The 3D finite element model of vascular smooth muscle cell (VSMC) presented here is based on hybrid modellingapproach, where the cytoplasm and the nucleus (violet) are modelled using continuum approach and the cytoskeleton is modelled using microstructural approach. The structural arrangement and elastic properties of the constituents of the cytoskeletal network are based on the experimental observations and measurements respectively and are obtained from the literature. The non-contractile actin cortex underneath the plasma membrane is modelled using shell elements, the actin bundles (light bl
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LO1202" target="_blank" >LO1202: NETME CENTRE PLUS</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů