Experimental methods for flow and aerosol measurements in human airways and their replicas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F18%3APU126175" target="_blank" >RIV/00216305:26210/18:PU126175 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0928098717304657" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0928098717304657</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejps.2017.08.021" target="_blank" >10.1016/j.ejps.2017.08.021</a>
Alternative languages
Result language
angličtina
Original language name
Experimental methods for flow and aerosol measurements in human airways and their replicas
Original language description
Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant differences among distinct methods of calculation emphasize the need for highly precise experimental data in order to specify boundary conditions and for validation purposes. This paper reviews and critically evaluates available methods for the measurement of single and disperse two-phase flows for the study of respiratory airflow and deposition of inhaled particles, performed both in vivo and in replicas of airways. Limitations and possibilities associated with the experimental methods are discussed and aspects of the computational calculations that can be validated are indicated. The review classifies the methods into following categories: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. All methods are described, applications in human airways studies are illustrated, and recommendations for the most useful applications of each method are given.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20301 - Mechanical engineering
Result continuities
Project
<a href="/en/project/GA16-23675S" target="_blank" >GA16-23675S: Multiscale laminar, transitional and turbulent accelerating and decelerating flow in human respiratory tract with aerosol transport and deposition</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN
0928-0987
e-ISSN
1879-0720
Volume of the periodical
113
Issue of the periodical within the volume
SI
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
37
Pages from-to
95-131
UT code for WoS article
000424975800009
EID of the result in the Scopus database
2-s2.0-85031301985