The effect of oral and nasal breathing on the deposition of inhaled particles in upper and tracheobronchial airways

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F20%3APU138273" target="_blank" >RIV/00216305:26210/20:PU138273 - isvavai.cz</a>

Alternative codes found

RIV/46356088:_____/20:N0000034 RIV/00209805:_____/20:00078465

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455204/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455204/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jaerosci.2020.105649" target="_blank" >10.1016/j.jaerosci.2020.105649</a>

Result language

angličtina

Original language name

The effect of oral and nasal breathing on the deposition of inhaled particles in upper and tracheobronchial airways

Original language description

The inhalation route has a substantial influence on the fate of inhaled particles. An outbreak of infectious diseases such as COVID-19, influenza or tuberculosis depends on the site of deposition of the inhaled pathogens. But the knowledge of respiratory deposition is important also for occupational safety or targeted delivery of inhaled pharmaceuticals. Simulations utilizing computational fluid dynamics are becoming available to a wide spectrum of users and they can undoubtedly bring detailed predictions of regional deposition of particles. However, if those simulations are to be trusted, they must be validated by experimental data. This article presents simulations and experiments performed on a geometry of airways which is available to other users and thus those results can be used for intercomparison between different research groups. In particular, three hypotheses were tested. First: Oral breathing and combined breathing are equivalent in terms of particle deposition in TB airways, as the pressure resistance of the nasal cavity is so high that the inhaled aerosol flows mostly through the oral cavity in both cases. Second: The influence of the inhalation route (nasal, oral or combined) on the regional distribution of the deposited particles downstream of the trachea is negligible. Third: Simulations can accurately and credibly predict deposition hotspots. The maximum spatial resolution of predicted deposition achievable by current methods was searched for. The simulations were performed using large-eddy simulation, the flow measurements were done by laser Doppler anemometry and the deposition has been measured by positron emission tomography in a realistic replica of human airways. Limitations and sources of uncertainties of the experimental methods were identified. The results confirmed that the high-pressure resistance of the nasal cavity leads to practically identical velocity profiles, even above the glottis for the mouth, and combined mouth and nose breath

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20401 - Chemical engineering (plants, products)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF AEROSOL SCIENCE

ISSN

0021-8502

e-ISSN

1879-1964

Volume of the periodical

150

Issue of the periodical within the volume

105649

Country of publishing house

GB - UNITED KINGDOM

Number of pages

23

Pages from-to

1-23

UT code for WoS article

000579770500011

EID of the result in the Scopus database

2-s2.0-85091236695