A Finite Element Bendo-Tensegrity Model of Eukaryotic Cell
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F18%3APU130351" target="_blank" >RIV/00216305:26210/18:PU130351 - isvavai.cz</a>
Result on the web
<a href="http://biomechanical.asmedigitalcollection.asme.org/article.aspx?articleid=2681670" target="_blank" >http://biomechanical.asmedigitalcollection.asme.org/article.aspx?articleid=2681670</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1115/1.4040246" target="_blank" >10.1115/1.4040246</a>
Alternative languages
Result language
angličtina
Original language name
A Finite Element Bendo-Tensegrity Model of Eukaryotic Cell
Original language description
Mechanical interaction of cell with extracellular environment affects its function. The mechanisms by which mechanical stimuli are sensed and transduced into biochemical responses are still not well understood. Considering this, two finite element (FE) bendo-tensegrity models of a cell in different states are proposed with the aim to characterize cell deformation under different mechanical loading conditions: a suspended cell model elucidating the global response of cell in tensile test simulation and an adherent cell model explicating its local response in atomic force microscopy (AFM) indentation simulation. The force-elongation curve obtained from tensile test simulation lies within the range of experimentally obtained characteristics of smooth muscle cells (SMCs) and illustrates a nonlinear increase in reaction force with cell stretching. The force-indentation curves obtained from indentation simulations lie within the range of experimentally obtained curves of embryonic stem cells (ESCs) and exhibit the influence of indentation site on the overall reaction force of cell. Simulation results have demonstrated that actin filaments (AFs) and microtubules (MTs) play a crucial role in the cell stiffness during stretching, whereas actin cortex (AC) along with actin bundles (ABs) and MTs are essential for the cell rigidity during indentation. The proposed models quantify the mechanical contribution of individual cytoskeletal components to cell mechanics and the deformation of nucleus under different mechanical loading conditions. These results can aid in better understanding of structure-function relationships in living cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/LO1202" target="_blank" >LO1202: NETME CENTRE PLUS</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
ISSN
0148-0731
e-ISSN
1528-8951
Volume of the periodical
140
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000447277300001
EID of the result in the Scopus database
2-s2.0-85050668206