Effect of Hyaluronic Acid Molecular Weight on Friction of Articular Cartilage

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F19%3APU132261" target="_blank" >RIV/00216305:26210/19:PU132261 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effect of Hyaluronic Acid Molecular Weight on Friction of Articular Cartilage
Original language description
Hyaluronic acid (HA) is among others one of the component of synovial fluid (SF) and is the main component which affects the rheology of SF. However, during various degenerative joint diseases like osteoarthritis, the concentration and molecular weight of HA in SF is decreasing. In recent times, injections with exogenous HA are gaining popularity as a one of the methods for non-invasive treatment of osteoarthritis. Exogenous HA should improve rheological properties of osteoarthritic SF and has also many physiological effects. One of the key parameters which affects the rheology of HA and the efficiency of viscosupplementation is the molecular weight of HA. In this study, the changes in coefficient of friction between intact porcine cartilage and glass plate during reciprocating sliding tests were analyzed to understand how the changes in molecular weight of HA affects the friction of articular cartilage model. The changes in friction between osteoarthritic SF and mixtures of SF and HA with different molecular weight were also analyzed to assess the significance of exogenous HA molecular weight on cartilage friction after viscosupplementation.
Czech name
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Czech description
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Project
<a href="/en/project/LTAUSA17150" target="_blank" >LTAUSA17150: The effect of tribological processes on the durability of knee joint replacements</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings on Engineering Sciences - 16th International Conference on Tribology
ISBN
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ISSN
2620-2832
e-ISSN
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Number of pages
5
Pages from-to
693-697
Publisher name
University of Kragujevac, Faculty of Engineering
Place of publication
Kragujevac
Event location
Kragujevac
Event date
May 15, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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