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A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F22%3APU144857" target="_blank" >RIV/00216305:26210/22:PU144857 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/22:10445166

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.35114" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.35114</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/jbm.b.35114" target="_blank" >10.1002/jbm.b.35114</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase

  • Original language description

    Osteoarthritis (OA) is one of the most common musculoskeletal disorders in the world. OA is often associated with the loss of viscoelastic and tribological properties of synovial fluid (SF) due to degradation of hyaluronic acid (HA) by reactive oxygen species (ROS) and hyaluronidases. Viscosupplementation is one of the ways how to effectively restore SF functions. However, current viscosupplementation products provide only temporal therapeutic effect because of short biological half-life. In this article we describe a novel device for viscosupplementation (NV) based on the cross-linked tyramine derivative of HA, chondroitin sulfate (CS), and high molecular weight HA by online determination of viscoelastic properties loss during degradation by ROS and hyaluronidase. Rheological and tribological properties of developed viscosupplement were compared with HA solutions with different molecular weights in the range 500–2000 kDa, which are currently commonly used as medical devices for viscosupplementation treatment. Moreover, based on clinical practice and scientific literature all samples were also diluted by model OA SF in the ratio 1:1 (vol/vol) to better predict final properties after injection to the joint. The observed results confirmed that NV exhibits appropriate rheological properties (viscosity, elastic, and viscous moduli) comparable with healthy SF and maintain them during degradation for a significantly longer time than HA solutions with molecular weight in the range 500–2000 kDa and cross-linked material without CS.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    20301 - Mechanical engineering

Result continuities

  • Project

    <a href="/en/project/GA20-00483S" target="_blank" >GA20-00483S: An investigation of synovial fluid viscosupplementation and its impact on friction and lubrication</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)

  • ISSN

    1552-4973

  • e-ISSN

    1552-4981

  • Volume of the periodical

    110

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    17

  • Pages from-to

    2595-2611

  • UT code for WoS article

    000813662300001

  • EID of the result in the Scopus database

    2-s2.0-85132142549