A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F22%3APU144857" target="_blank" >RIV/00216305:26210/22:PU144857 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10445166
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.35114" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.35114</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jbm.b.35114" target="_blank" >10.1002/jbm.b.35114</a>
Alternative languages
Result language
angličtina
Original language name
A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase
Original language description
Osteoarthritis (OA) is one of the most common musculoskeletal disorders in the world. OA is often associated with the loss of viscoelastic and tribological properties of synovial fluid (SF) due to degradation of hyaluronic acid (HA) by reactive oxygen species (ROS) and hyaluronidases. Viscosupplementation is one of the ways how to effectively restore SF functions. However, current viscosupplementation products provide only temporal therapeutic effect because of short biological half-life. In this article we describe a novel device for viscosupplementation (NV) based on the cross-linked tyramine derivative of HA, chondroitin sulfate (CS), and high molecular weight HA by online determination of viscoelastic properties loss during degradation by ROS and hyaluronidase. Rheological and tribological properties of developed viscosupplement were compared with HA solutions with different molecular weights in the range 500–2000 kDa, which are currently commonly used as medical devices for viscosupplementation treatment. Moreover, based on clinical practice and scientific literature all samples were also diluted by model OA SF in the ratio 1:1 (vol/vol) to better predict final properties after injection to the joint. The observed results confirmed that NV exhibits appropriate rheological properties (viscosity, elastic, and viscous moduli) comparable with healthy SF and maintain them during degradation for a significantly longer time than HA solutions with molecular weight in the range 500–2000 kDa and cross-linked material without CS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20301 - Mechanical engineering
Result continuities
Project
<a href="/en/project/GA20-00483S" target="_blank" >GA20-00483S: An investigation of synovial fluid viscosupplementation and its impact on friction and lubrication</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)
ISSN
1552-4973
e-ISSN
1552-4981
Volume of the periodical
110
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
2595-2611
UT code for WoS article
000813662300001
EID of the result in the Scopus database
2-s2.0-85132142549