Numerical simulation of fibre deposition in oral and large bronchial airways in comparison with experiments

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F19%3APU132483" target="_blank" >RIV/00216305:26210/19:PU132483 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0021850218304373?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0021850218304373?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jaerosci.2019.06.003" target="_blank" >10.1016/j.jaerosci.2019.06.003</a>

Result language
angličtina
Original language name
Numerical simulation of fibre deposition in oral and large bronchial airways in comparison with experiments
Original language description
Inhaled asbestos fibres have been implicated in causal relationships with increased frequencies of non-malignant pleural disease, asbestosis, mesothelioma and lung cancer. Replacement fibres are considered to be less harmful, however, their health effects are not fully understood. The objective of the present work was to implement and apply numerical fibre tracking techniques in order to simulate the deposition of fibres in a complex oro-pharyngeal-laryngeal-bronchial system at different inhalation flow rates and compare the results with the outcomes of recent measurements performed in the same geometry. Two different approaches for the estimation of drag force were considered. Simulated deposition efficiency values agreed reasonably well with the experimentally determined values, however, the drag model which considers the anisotropic nature of the geometry of fibres performed better than the one which accounted only for the their non-spherical shape. The highest values of deposition density correlated well with the location of primary lesions observed in pathological studies.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20301 - Mechanical engineering

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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