Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F19%3APU134653" target="_blank" >RIV/00216305:26210/19:PU134653 - isvavai.cz</a>
Result on the web
<a href="http://cas.icpf.cas.cz/download/Sbornik_VKCAS_2019.pdf" target="_blank" >http://cas.icpf.cas.cz/download/Sbornik_VKCAS_2019.pdf</a>
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions
Original language description
Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.
Czech name
—
Czech description
—

Project
<a href="/en/project/GA18-25618S" target="_blank" >GA18-25618S: Research of the effect of the non-stationary flow on the transport of fibers in successively bifurcating mini-channels</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)