The Effect of Albumin and γ-globulin on Synovial Fluid Lubrication: Implication for Knee Joint Replacements

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F21%3APU137355" target="_blank" >RIV/00216305:26210/21:PU137355 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/21:73608615

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1751616120306652" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1751616120306652</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jmbbm.2020.104117" target="_blank" >10.1016/j.jmbbm.2020.104117</a>

Result language

angličtina

Original language name

The Effect of Albumin and γ-globulin on Synovial Fluid Lubrication: Implication for Knee Joint Replacements

Original language description

Total knee arthroplasty has become a routine procedure for patients suffering from joint diseases. Although the number of operations continuously increases, a limited service-life of implants represents a persisting challenge for scientists. Understanding of lubrication may help to suitably explain tribological processes on the way to replacements that become durable well into the third decade of service. The aim of the present study is to assess the formation of protein lubricating film in the knee implant. A developed knee simulator was used to observe the contact of real femoral and transparent polymer tibial component using fluorescent microscopy. The contact was lubricated by various protein solutions with attention to the behaviour of albumin and γ-globulin. In order to suitably mimic a human synovial fluid, hyaluronic acid and phospholipids were subsequently added to the solutions. Further, the change in shape and the migration of the contact zone were studied. The results showed considerable appearance differences of the contact over the swing phase of the simplified gait cycle. Regarding film formation, a strong interaction of the various molecules of synovial fluid was observed. It was found that the thickness of the lubricating layer stabilizes within around 50 seconds. Throughout the contact zone, protein agglomerations were present and could be clearly visualised using the applied optical technique.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20301 - Mechanical engineering

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the mechanical behavior of biomedical materials

ISSN

1751-6161

e-ISSN

1878-0180

Volume of the periodical

113

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

104117-104117

UT code for WoS article

000599818300004

EID of the result in the Scopus database

2-s2.0-85092361148