Finite Element Simulations of Mechanical Behaviour of Endothelial Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F21%3APU139825" target="_blank" >RIV/00216305:26210/21:PU139825 - isvavai.cz</a>
Result on the web
<a href="https://www.hindawi.com/journals/bmri/2021/8847372/" target="_blank" >https://www.hindawi.com/journals/bmri/2021/8847372/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2021/8847372" target="_blank" >10.1155/2021/8847372</a>
Alternative languages
Result language
angličtina
Original language name
Finite Element Simulations of Mechanical Behaviour of Endothelial Cells
Original language description
Biomechanical models based on the finite element method have already shown their potential in the simulation of the mechanical behaviour of cells. For instance, development of atherosclerosis is accelerated by damage of the endothelium, a monolayer of endothelial cells on the inner surface of arteries. Finite element models enable us to investigate mechanical factors not only at the level of the arterial wall but also at the level of individual cells. To achieve this, several finite element models of endothelial cells with different shapes are presented in this paper. Implementing the recently proposed bendotensegrity concept, these models consider the flexural behaviour of microtubules and incorporate also waviness of intermediate filaments. The suspended and adherent cell models are validated by comparison of their simulated force-deformation curves with experiments from the literature. The flat and dome cell models, mimicking natural cell shapes inside the endothelial layer, are then used to simulate their response in compression and shear which represent typical loads in a vascular wall. The models enable us to analyse the role of individual cytoskeletal components in the mechanical responses, as well as to quantify the nucleus deformation which is hypothesized to be the quantity decisive for mechanotransduction.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20801 - Environmental biotechnology
Result continuities
Project
<a href="/en/project/GA18-13663S" target="_blank" >GA18-13663S: COMPUTATIONAL MODELLING OF RUPTURE RISK OF ATHEROSCLEROTIC PLAQUES IN CAROTID ARTERIES</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BioMed Research International
ISSN
2314-6133
e-ISSN
2314-6141
Volume of the periodical
2021
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
1-17
UT code for WoS article
000625275000003
EID of the result in the Scopus database
2-s2.0-85102063958