Bendo-tensegrity model simulates compression test of animal cell
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F18%3APU130037" target="_blank" >RIV/00216305:26210/18:PU130037 - isvavai.cz</a>
Result on the web
<a href="http://www.engmech.cz/improc/2018/45.pdf" target="_blank" >http://www.engmech.cz/improc/2018/45.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21495/91-8-45" target="_blank" >10.21495/91-8-45</a>
Alternative languages
Result language
angličtina
Original language name
Bendo-tensegrity model simulates compression test of animal cell
Original language description
A hybrid model of suspended animal cell proposed earlier, with a bendo-tensegrity structure mimicking cytoskeleton, is applied to simulate the global response of the cell under compression and to describe mechanical behaviour of its components. The Finite Element model incorporates Microtubules, Actin Filaments, Intermediate Filaments, nucleus, cytoplasm, and Cell Membrane, all of them with realistic geometrical and material parameters. The unique features of this structural model keep fundamental principles governing cell behaviour, such as interaction between the cytoskeletal components redistributing the prestress of actin filaments throughout all the structure. The force-deformation curve from the simulated compression test with microplates is validated by comparison with the experimental response from literature. The model enables us to investigate the mechanical role of individual celular and cytoskeletal components in intracellular force propagation by means of changing their numbers or parameters. As quantitative characterization of nucleus deformation may be hypothetically decisive for mechanotransduction, the model aims at better understanding of how cellular processes are mechanically controlled.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Engineering Mechanics 2018
ISBN
978-80-86246-88-8
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
45-48
Publisher name
Neuveden
Place of publication
Neuveden
Event location
Svratka
Event date
May 14, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000465489800011