Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F21%3APU140962" target="_blank" >RIV/00216305:26210/21:PU140962 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/21:00554894 RIV/61988987:17310/21:A2202A6K RIV/62156489:43110/21:43919672 RIV/00216224:14310/21:00121411
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0300908421000961" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0300908421000961</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biochi.2021.03.017" target="_blank" >10.1016/j.biochi.2021.03.017</a>

Result language
angličtina
Original language name
Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection
Original language description
G-quadruplexes contribute to the regulation of key molecular processes. Their utilization for antiviral therapy is an emerging field of contemporary research. Here we present comprehensive analyses of the presence and localization of putative G-quadruplex forming sequences (PQS) in all viral genomes currently available in the NCBI database (including subviral agents). The G4Hunter algorithm was applied to a pool of 11,000 accessible viral genomes representing 350 Mbp in total. PQS frequencies differ across evolutionary groups of viruses, and are enriched in repeats, replication origins, 5′UTRs and 3′UTRs. Importantly, PQS presence and localization is connected to viral lifecycles and corresponds to the type of viral infection rather than to nucleic acid type; while viruses routinely causing persistent infections in Metazoa hosts are enriched for PQS, viruses causing acute infections are significantly depleted for PQS. The unique localization of PQS identifies the importance of G-quadruplex-based regulation of viral replication and life cycle, providing a tool for potential therapeutic targeting.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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