Tracing dsDNA Virus-Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F21%3A00542171" target="_blank" >RIV/68081707:_____/21:00542171 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26210/21:PU140956 RIV/00216224:14310/21:00121350
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/7/3433" target="_blank" >https://www.mdpi.com/1422-0067/22/7/3433</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22073433" target="_blank" >10.3390/ijms22073433</a>
Alternative languages
Result language
angličtina
Original language name
Tracing dsDNA Virus-Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences
Original language description
The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/EF15_003%2F0000477" target="_blank" >EF15_003/0000477: Structural gymnastics of nucleic acids: from molecular principles through biological functions to therapeutic targets.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
22
Issue of the periodical within the volume
7
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
3433
UT code for WoS article
000638616100001
EID of the result in the Scopus database
2-s2.0-85103058094