Tracing dsDNA Virus-Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F23%3APU150743" target="_blank" >RIV/00216305:26210/23:PU150743 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43110/23:43923452
Result on the web
<a href="https://mdpi-res.com/bookfiles/book/7184/Impacts_of_Molecular_Structure_on_Nucleic_AcidProtein_Interactions.pdf?v1683119827" target="_blank" >https://mdpi-res.com/bookfiles/book/7184/Impacts_of_Molecular_Structure_on_Nucleic_AcidProtein_Interactions.pdf?v1683119827</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Tracing dsDNA Virus-Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences
Original language description
The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization.
Czech name
—
Czech description
—
Classification
Type
C - Chapter in a specialist book
CEP classification
—
OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Impacts of Molecular Structure on Nucleic Acid-Protein Interactions
ISBN
978-3-0365-7444-8
Number of pages of the result
12
Pages from-to
39-50
Number of pages of the book
203
Publisher name
Neuveden
Place of publication
Neuveden
UT code for WoS chapter
—