YAP Signaling Regulates the Cellular Uptake and Therapeutic Effect of Nanoparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F24%3APU155941" target="_blank" >RIV/00216305:26210/24:PU155941 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/24:00135260 RIV/00159816:_____/23:00079679
Result on the web
<a href="https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202302965" target="_blank" >https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202302965</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/advs.202302965" target="_blank" >10.1002/advs.202302965</a>
Alternative languages
Result language
angličtina
Original language name
YAP Signaling Regulates the Cellular Uptake and Therapeutic Effect of Nanoparticles
Original language description
Interactions between living cells and nanoparticles are extensively studied to enhance the delivery of therapeutics. Nanoparticles size, shape, stiffness, and surface charge are regarded as the main features able to control the fate of cell-nanoparticle interactions. However, the clinical translation of nanotherapies has so far been limited, and there is a need to better understand the biology of cell-nanoparticle interactions. This study investigates the role of cellular mechanosensitive components in cell-nanoparticle interactions. It is demonstrated that the genetic and pharmacologic inhibition of yes-associated protein (YAP), a key component of cancer cell mechanosensing apparatus and Hippo pathway effector, improves nanoparticle internalization in triple-negative breast cancer cells regardless of nanoparticle properties or substrate characteristics. This process occurs through YAP-dependent regulation of endocytic pathways, cell mechanics, and membrane organization. Hence, the study proposes targeting YAP may sensitize triple-negative breast cancer cells to chemotherapy and increase the selectivity of nanotherapy. The inhibition of Yeas-associated protein (YAP) in TNBC cells affects the organization of plasma membrane, reduces the extracellular matrix (ECM) deposition, impacts their adhesion ability, and increases the endocytosis rate. Thus, targeting cell mechanobiology may be leveraged to optimize cell-nanoparticle interactions. Ultimately, these changes contribute cooperatively to promote the delivery of nanomedicines to cancer cells and improve the therapeutic efficiency.image
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10400 - Chemical sciences
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Science
ISSN
2198-3844
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
„“-„“
UT code for WoS article
001121056800001
EID of the result in the Scopus database
2-s2.0-85176121090