G-quadruplex motifs prediction and visualization in Sus scrofa genome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F26%3A0200031" target="_blank" >RIV/00216305:26210/26:0200031 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0888754325001843" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0888754325001843</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ygeno.2025.111168" target="_blank" >10.1016/j.ygeno.2025.111168</a>
Alternative languages
Result language
angličtina
Original language name
G-quadruplex motifs prediction and visualization in Sus scrofa genome
Original language description
Sus scrofa is not only a key agricultural species but also a valuable biomedical model due to its physiological and anatomical similarities to humans. We present a comprehensive genome-wide analysis of putative G-quadruplexforming sequences (PQS) in the pig genome, with a focus on their distribution within regulatory and functionally relevant genomic regions. Our results demonstrate that PQS are non-randomly distributed, showing significant enrichment in promoter regions, untranslated regions, and other regulatory elements. These distribution patterns closely parallel those observed in the human genome, suggesting a conserved role for G-quadruplexes (G4s) across species. Importantly, we provide experimental validation of G4 structures in cells in situ of porcine dorsal skin samples using the G4-specific antibody SG4, confirming their presence at the cellular level. The high degree of similarity in PQS localization between pigs and humans highlights the translational potential of Sus scrofa for studying G4 biology and evaluating G4-targeted therapeutic strategies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2026
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genomics
ISSN
0888-7543
e-ISSN
1089-8646
Volume of the periodical
118
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1-8
UT code for WoS article
001640955100001
EID of the result in the Scopus database
2-s2.0-105024317269