Abundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F24%3A00582377" target="_blank" >RIV/68081707:_____/24:00582377 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26310/24:PU150670
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsomega.3c09288" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.3c09288</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.3c09288" target="_blank" >10.1021/acsomega.3c09288</a>

Result language
angličtina
Original language name
Abundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomes
Original language description
Hepatitis delta virus (HDV) is a highly unusual RNA satellite virus that depends on the presence of hepatitis B virus (HBV) to be infectious. Its compact and variable single-stranded RNA genome consists of eight major genotypes distributed unevenly across different continents. The significance of noncanonical secondary structures such as G-quadruplexes (G4s) is increasingly recognized at the DNA and RNA levels, particularly for transcription, replication, and translation. G4s are formed from guanine-rich sequences and have been identified in the vast majority of viral, eukaryotic, and prokaryotic genomes. In this study, we analyzed the G4 propensity of HDV genomes by using G4Hunter. Unlike HBV, which has a G4 density similar to that of the human genome, HDV displays a significantly higher number of potential quadruplex-forming sequences (PQS), with a density more than four times greater than that of the human genome. This finding suggests a critical role for G4s in HDV, especially given that the PQS regions are conserved across HDV genotypes. Furthermore, the prevalence of G4-forming sequences may represent a promising target for therapeutic interventions to control HDV replication.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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