Anthracycline Therapy and 24-Hour Blood-Pressure Profile in Long-Term Survivors of Childhood Cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F10%3APU88677" target="_blank" >RIV/00216305:26220/10:PU88677 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/10:#0000955 RIV/00216224:14110/10:00051469
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Anthracycline Therapy and 24-Hour Blood-Pressure Profile in Long-Term Survivors of Childhood Cancer
Original language description
In our previous studies, a decreased blood pressure was reported in children treated by anthracycline (AC). The aim of this study was to assess the long-term effects of AC anticancer therapy in 45 subjects aged 13-22 years by repeated 24-hour Holter monitoring of blood pressure. Sixty four aged-matched subjects served as controls. The differences between mean values of systolic (SBP) and diastolic blood pressure (DBP) in each hour of both groups were evaluated by Mann-Whitney test. Also the parameters of the least-squares fit of the sinusoidal curve in each subject were estimated (M - mesor, midline-estimating, a mean value of sinusoidal curve corresponds to 24-hours mean pressure; A amplitude, double amplitude corresponds to night-day difference; Acr- acrophase is a time of maximal value of a sinusoidal curve). SBP and DBP was significantly lower only during night hours in anthracycline patients 19-22 years old. Also M was lower in this age subgroup of patients comparing to age match
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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