Heat Generation in Biological Tissues during Photodynamic Therapy combined with Gold Nanoparticles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F12%3APU98221" target="_blank" >RIV/00216305:26220/12:PU98221 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Heat Generation in Biological Tissues during Photodynamic Therapy combined with Gold Nanoparticles

Original language description

One of the emerging strategies to overcome the actual drawbacks in Photodynamic Therapy is its combination with nanoparticles. Specifically, the administration of gold nanoparticles to the pathological tissue causes an increase in the optical radiation absorption that could lead to induce thermal damage in the target tissue. However, photodynamic therapy is based on photochemical interactions and therefore it is necessary to study possible thermal interactions that might occur in the target tissue due to the administration of nanoparticles. In this work we present a thermal model that tries to predict the effect of gold nanoparticles in the local heating for three different types of malignant skin tumors subjected to typical power densities applied inphotodynamic therapy. The results obtained show a negligible increase in the local temperature that demonstrates the absence of thermal damage under the irradiation conditions commonly applied in photodynamic therapy clinical practice.

Czech name

Heat Generation in Biological Tissues during Photodynamic Therapy combined with Gold Nanoparticles

Czech description

One of the emerging strategies to overcome the actual drawbacks in Photodynamic Therapy is its combination with nanoparticles. Specifically, the administration of gold nanoparticles to the pathological tissue causes an increase in the optical radiation absorption that could lead to induce thermal damage in the target tissue. However, photodynamic therapy is based on photochemical interactions and therefore it is necessary to study possible thermal interactions that might occur in the target tissue due to the administration of nanoparticles. In this work we present a thermal model that tries to predict the effect of gold nanoparticles in the local heating for three different types of malignant skin tumors subjected to typical power densities applied inphotodynamic therapy. The results obtained show a negligible increase in the local temperature that demonstrates the absence of thermal damage under the irradiation conditions commonly applied in photodynamic therapy clinical practice.

Type

D - Article in proceedings

CEP classification

JA - Electronics and optoelectronics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings of 22nd International Conference Radioelektronika 2012

ISBN

978-80-214-4468-3

ISSN

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e-ISSN

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Number of pages

4

Pages from-to

183-186

Publisher name

Neuveden

Place of publication

Neuveden

Event location

Brno

Event date

Apr 17, 2012

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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