Effect Of Cognitive Stimulation On Hippocampal Ripples In Epileptic Patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F13%3APU105035" target="_blank" >RIV/00216305:26220/13:PU105035 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.jns.2013.07.131" target="_blank" >http://dx.doi.org/10.1016/j.jns.2013.07.131</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2013.07.131" target="_blank" >10.1016/j.jns.2013.07.131</a>

Result language

angličtina

Original language name

Effect Of Cognitive Stimulation On Hippocampal Ripples In Epileptic Patients

Original language description

Interictal HFOs (ripples and fast ripples) have been repeatedly identified in recordings from depth macroelectrodes in epileptics. In contrast to fast ripples, which are believed to reflect the neuronal substrates of epileptogenicity, ripples are considered to be a signature of both normal and epileptic brain processes. The differentiation of physiological and epileptic ripples in intracranial recordings remains unavailable. We analyzed SEEG recordings in seven patients with intractable partial seizures in whom hippocampal activity was recorded in resting state and subsequently during simple cognitive task with randomly presented frequent and rare visual stimuli. Using automated detection of ripples based on length of power envelope, we analyzed potentia l differences in ripple rate (RR) in the cognitive vs. resting period, within epileptic (EH) and nonepileptic hippocampi (NH). Further direct impact of cognitive stimuli on ripples (immediately after the stimulus) was investigated. Ripples have been detected within hippocampal recordings in all the investigated subjects. Mean RR in resting periods was 11.36 +/- 8.34/min within EH, and 10.13 +/- 8.75/min within NH. In the cognitive task periods mean RR within EH and NH decreased to 7.16 +/-5.75/min, and 8.75 +/- 7.69/min respectively. The reduction of RR during cognitive stimulation was significant in EH, but not in NH. Interestingly we observed a transient suppression of ripples in both EH (slight) and NH (significant) in the first second after the stimuli onset, followed by a significant increase in RR for both EH and NH. Our results point to different reactivity of ripples within EH and NH to the cognitive stimulation.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Epilepsia

ISBN

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ISSN

1300-1817

e-ISSN

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Number of pages

1

Pages from-to

1-1

Publisher name

Neuveden

Place of publication

Neuveden

Event location

Montreal

Event date

Jun 23, 2013

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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