Phytol Derivatives as Drug Resistance Reversal Agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F14%3APU110115" target="_blank" >RIV/00216305:26220/14:PU110115 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/cmdc.201402027" target="_blank" >http://dx.doi.org/10.1002/cmdc.201402027</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cmdc.201402027" target="_blank" >10.1002/cmdc.201402027</a>
Alternative languages
Result language
angličtina
Original language name
Phytol Derivatives as Drug Resistance Reversal Agents
Original language description
Phytol was chemically transformed into fifteen semi-synthetic derivatives, which were evaluated for their antibacterial and drug resistance reversal potential in combination with nalidixic acid against E. coli strains CA8000 and DH5a. The pivaloyl (4), 3,4,5-trimethoxybenzoyl (9), 2,3-dichlorobenzoyl (10), cinnamoyl (11), and aldehyde (14) derivatives of phytol ((2E,7R,11R)- 3,7,11,15-tetramethyl-2-hexadecen-1-ol) were evaluated by using another antibiotic, tetracycline, against the MDREC-KG4 clinical isolate of E. coli. Derivative 4 decreased the maximal inhibitory concentration (MIC) of the antibiotics by 16-fold, while derivatives 9, 10, 11, and 14 reduced MIC values of the antibiotics up to eightfold against the E. coli strains. Derivatives 4, 9, 10, 11, and 14 inhibited the ATP-dependent efflux pump; this was also supported by their in silico binding affinity and down-regulation of the efflux pump gene yojI, which encodes the multidrug ATP-binding cassette transporter protein. This study supports the possible use of phytol derivatives in the development of cost-effective antibacterial combinations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
<a href="/en/project/EE2.3.30.0039" target="_blank" >EE2.3.30.0039: Excellent young researcher at BUT</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemMedChem
ISSN
1860-7179
e-ISSN
1860-7187
Volume of the periodical
9
Issue of the periodical within the volume
8
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
1860-1868
UT code for WoS article
000340360500023
EID of the result in the Scopus database
2-s2.0-84905220891