Gallic acid based indanone derivative interacts synergistically with tetracycline by inhibiting efflux pump in multidrug resistant E. coli

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F16%3APU117767" target="_blank" >RIV/00216305:26220/16:PU117767 - isvavai.cz</a>

Result on the web

<a href="http://link.springer.com/article/10.1007/s00253-015-7152-6" target="_blank" >http://link.springer.com/article/10.1007/s00253-015-7152-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00253-015-7152-6" target="_blank" >10.1007/s00253-015-7152-6</a>

Result language

angličtina

Original language name

Gallic acid based indanone derivative interacts synergistically with tetracycline by inhibiting efflux pump in multidrug resistant E. coli

Original language description

The purpose of the present study was to study the synergy potential of gallic acid-based derivatives in combination with conventional antibiotics using multidrug resistant cultures of Escherichia coli. Gallic acid-based derivatives significantly reduced the MIC of tetracycline against multidrug resistant clinical isolate of E. coli. The best representative, 3-(3,4,5-trimethoxyphenyl)-4,5,6-trimethoxyindanone-1, an indanone derivative of gallic acid, was observed to inhibit ethidium bromide efflux and ATPase which was also supported by in silico docking. This derivative extended the post-antibiotic effect and decreased the mutation prevention concentration of tetracycline. This derivative in combination with TET was able to reduce the concentration of TNFα up to 18-fold in Swiss albino mice. This derivative was nontoxic and well tolerated up to 300 mg/kg dose in subacute oral toxicity study in mice. This is the first report of gallic acid-based indanone derivative as drug resistance reversal agent acting through ATP-dependent efflux pump inhibition.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

ISSN

0175-7598

e-ISSN

1432-0614

Volume of the periodical

100

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

15

Pages from-to

2311-2325

UT code for WoS article

000371243500025

EID of the result in the Scopus database

2-s2.0-84958900207