Voltage Sensitive Dye di-4-ANNEPS Prolongs Impulse Conduction Through Ventricles, but not Through AV Node in Isolated Rabbit Heart

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F15%3APU116284" target="_blank" >RIV/00216305:26220/15:PU116284 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/15:00081269
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Voltage Sensitive Dye di-4-ANNEPS Prolongs Impulse Conduction Through Ventricles, but not Through AV Node in Isolated Rabbit Heart
Original language description
Voltage sensitive dyes are widely used for measurement of action potential in various cardiac studies. The elementary condition for its application is fact that measured electrophysiological parameters would not be affected by measuring procedure itself.The prolongation of RR interval in the presence of the most used voltage sensitive dye di-4-ANEPPS has been reported, however the exact mechanism is not known. In this study we examine impact of di-4-ANEPPS on impulse conduction through the atrioventricular (AV) node and cardiac ventricles in isolated rabbit heart. The impulse conduction through AV node in presence of di-4-ANEPPS was prolonged only in phase of dye loading at 14th, 16th and 17th minute. Only sporadic AV block was observed. In comparison, the prolongation of impulse conduction through cardiac ventricles was observed after 13th minute of dye loading and persisted to the end of this phase as well as over the whole wash out phase.
Czech name
—
Czech description
—

Project
<a href="/en/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analysis of Relationship between Electrical Activity and Blood Flow at the Heart Ventricles</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)