The Effect of Voltage-Sensitive Dye di-4-ANEPPS on Heart Rate Variability in Langendorff-Perfused Isolated Rabbit Heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F15%3APU116286" target="_blank" >RIV/00216305:26220/15:PU116286 - isvavai.cz</a>
Result on the web
<a href="https://ieeexplore.ieee.org/document/7411094" target="_blank" >https://ieeexplore.ieee.org/document/7411094</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1109/CIC.2015.7411094" target="_blank" >10.1109/CIC.2015.7411094</a>
Alternative languages
Result language
angličtina
Original language name
The Effect of Voltage-Sensitive Dye di-4-ANEPPS on Heart Rate Variability in Langendorff-Perfused Isolated Rabbit Heart
Original language description
Optical mapping of heart electrical activity in Langendorff-perfused isolated hearts is based on voltage-sensitive dyes, of which the most commonly used one is di-4-ANEPPS. Prolongation of action potential duration by di-4-ANEPPS was reported in isolated cells; however, this phenomenon was not observed in the whole heart model. In order to search for other adverse phenomena of di-4-ANEPPS use, its effect on heart rate variability (HRV) was investigated during staining and washout periods in five New Zealand White rabbit isolated hearts. Time domain, frequency domain and non-linear HRV parameters (21 in total) revealed that there are no significant changes between control, staining and washout periods. Voltage-sensitive dye di-4-ANEPPS does not affect HRV when applied into the isolated heart coronary system. It can be concluded that di-4-ANEPPS may be safely used in studies combining optical mapping and HRV analysis.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])
Result continuities
Project
<a href="/en/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analysis of Relationship between Electrical Activity and Blood Flow at the Heart Ventricles</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Computing in Cardiology 2015
ISBN
978-1-4799-4347-0
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
1049-1052
Publisher name
Neuveden
Place of publication
Nice, Francie
Event location
Nice, France
Event date
Sep 6, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000380374700264