The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F16%3APU120607" target="_blank" >RIV/00216305:26220/16:PU120607 - isvavai.cz</a>
Result on the web
<a href="https://ieeexplore.ieee.org/document/7868789" target="_blank" >https://ieeexplore.ieee.org/document/7868789</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.22489/CinC.2016.143-254" target="_blank" >10.22489/CinC.2016.143-254</a>

Result language
angličtina
Original language name
The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart
Original language description
Presence of heart rate variability (HRV) in isolated hearts is widely recognized; however, its mechanisms are still subject of debate. One of the possible explanations is that mechanoreceptors in cardiac tissue affect HRV. In order to evaluate possible dependence of HRV on heart mechanoreceptors activated during left ventricle filling, the HRV parameters in two perfusion modes of isolated heart were compared: Langendorff and working heart mode. Ten New Zealand rabbit isolated hearts were perfused (Krebs-Henseleit, 37 degrees C, 85 mmHg) in Langendorff mode and consecutively in working heart mode (8 cmH(2)O preload, 60 cmH(2)O afterload). A total of 27 HRV parameters in time, frequency, geometric, and non-linear domain were computed. No significant differences (Wilcoxon signed rank test, p < 0.05) were found among all studied HRV parameters between Langendorff and working heart mode. The study confirms the presence of heart rate fluctuation in isolated hearts in both Langendorff and working heart modes. Results of statistical analysis show that heart rate fluctuation is irrespective to mechanical stimulation of heart during atrium and ventricle filling.
Czech name
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Czech description
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Type
D - Article in proceedings
CEP classification
—
OECD FORD branch
20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project
<a href="/en/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analysis of Relationship between Electrical Activity and Blood Flow at the Heart Ventricles</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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