The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F17%3APU125221" target="_blank" >RIV/00216305:26220/17:PU125221 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.22489/CinC.2017.150-161" target="_blank" >http://dx.doi.org/10.22489/CinC.2017.150-161</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.22489/CinC.2017.150-161" target="_blank" >10.22489/CinC.2017.150-161</a>
Alternative languages
Result language
angličtina
Original language name
The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats
Original language description
Deeper understanding of heart rate variability (HRV) changes induced by haloperidol administration can contribute to overcoming of adverse cardiovascular effects of antipsychotics. The effect of haloperidol administration on HRV was therefore studied in nine schizophrenia-like rat isolated hearts and six control rat hearts. Isolated hearts were stabilized (20 min) on Langendorff perfusion system, then exposed to haloperidol (40 min) and finally washed out (40 min). The effect of haloperidol administration was studied in tachograms obtained from touchless-recorded electrograms (5 kHz, 12-bit). HRV parameters evolution in time, frequency, geometric, and non-linear domain were computed from 10 minutes long tachogram segments during stabilization, haloperidol exposition and washout periods. The haloperidol administration significantly affected HRV parameters in control rat hearts, but it had limited effect on schizophrenia-like ones. The effect of haloperidol administration was irreversible, since the washout did not restore HRV parameters to their initial values.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analysis of Relationship between Electrical Activity and Blood Flow at the Heart Ventricles</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Computing in Cardiology, 2017
ISBN
978-1-5090-0684-7
ISSN
0276-6574
e-ISSN
—
Number of pages
4
Pages from-to
1-4
Publisher name
Computing in Cardiology 2017
Place of publication
Rennes, France
Event location
Rennes
Event date
Sep 24, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000450651100129